The extract of leaves and seeds of ginkgo, Ginkgo biloba L. (Ginkgoaceae) in the treatment and profilaxis of ischemia
Abstract
Ginkgo biloba L., a plant species from the family Ginkgoaceae, has been described concerning its therapeutical uses since 2800 bC, and its extract coded as EGb 761 has been traded for over two decades. This survey aimed to assemble evidences on the effects of EGb 761 extract on prophylaxis and therapeutics o ischemia, published along the last five years. In this extract, Flavonoids has been associated with the antioxidant and the anti-free-radical actions, preventing oxidative damage by reperfusion after ischemia, besides improving brain metabolism. Terpenoid markers have been associated with heart protective, acting together with flavonoids. Bilobalides has been cited as responsible by neuronal protection, and by the prevention of ischemic damage. Ginkgolides may be indicated in the inflammation treatment, transplant rejection, asthma, by means of an antioxidant mechanism, and in ischemic damages as antagonist of the Platlet Aggregation Factor – PAF.
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Calapai G, Crupi A, Firenzuoli F, Marciano MC, Squadrito F, Inferrera G, Parisi A, Rizzo A, Crisafulli C, Fiore A & Caputi AP (2000) Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis. Life Sciences 67: 2673-2683.
Chandrasekaran K, Mehrabian Z, Spinnewyn B, Chinopoulos C, Drieu K & Fiskum G (2003) Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry 36: S89-94.
Chen C, Wei T, Gao Z, Zhao B, Hou J, Xu H, Xin W & Packer L (1999) Different effects of the constituints of EGb 761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals. Biochemistry and Molecular Biology 47: 397-405.
Christen Y & Maixent Jm (2002) What is Gingko biloba extract EGb 761? An overview - from molecular biology to clinical medicine. Cellular and Molecular Biology 48: 601-611.
Clostre F (1999) Extrait du Ginkgo biloba (EGb761). Etat des connaissances à l’aube de l’an 2000. Annales Pharmaceutiques 57: 1S8-1S88.
Dajas F, Rivera F, Blasina F, Arredondo F, Echeverry C, Lafon L, Morquio A & Heizen H (2003) Cell culture protection and in vivo neuroprotective capacity of flavonoids. Neurotoxicity Research 5: 425-432.
DeFeudis FV & Drieu K (2000) Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Current Drug Targets 1: 25-58.
Gold PE, Cahill L & Wenk Gl (2003) As controvérsias do Ginkgo biloba. Scientific American Brasil 2. 84-89.
Huang SH, Duke RK, Chebib M, Sasaki K, Wada K & Johnston GA (2003) Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1, beta2, gamma2L GABA(A) receptors. European Journal of Pharmacology 464: 1-8.
Janssens D, Remacle J, Drieu K & Michiels C (1999) Protection of mitochondrial respiration activity by bilobalide. Biochemical Pharmacology 58: 109-119.
Koch E (2005) Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 12: 10-16.
Kusmic C, Basta G, Lazzerini G, Vesentini N & Barsacchi R (2004) The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart: a link between vitamin E preservation and prostaglandin biosynthesis. Journal of Cardiovascular Pharmacology 44: 356-62.
Liebgott T, Miollan M, Berchadsky Y, Drieu K, Culcasi M & Pietri S (2000) Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract (EGb 761) during ischemia and reperfusion. Basic Research in Cardiology 95: 368-377.
Mauri P, de Palma A, Pozzi F, Basilico F, Riva A, Morazzoni P, Bombardelli E & Rossoni G (2006) LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts correlation with pharmacological activity Journal of Pharmaceutical and Biomedical Analysis 40: 763-768.
Massieu L, Morán J & Christen Y (2004) Effect of Ginkgo biloba (EGb 761) on staurosporin-induced neuronal death and caspase activity in cortical cultured neurons. Brain Research 1002: 76-85.
Nathan Pj, Tanner S, Lloyd J, Harrison B, Curren L, Oliver C & Stough C (2004) Effects of a combined extract of Gingko biloba and Bacopa monniera on cognitive function in healthy humans. Human Psychopharmacology – Clinical and Experimental 19: 91-96.
Ni Y, Chen C, Zhao B, Hou J & Xin W (1996) Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals. Neuroscience Letters 214: 115-118.
Pierr S, Jamme I, Robert K, Gerbi A, Duran Mj, Sennoune S, Droy-Lefaix MT, Nouvelot A & Maixent
JM (2002) Ginkgo biloba extract (EGb 761) protects Na-K-ATPase isoenzymes during cerebral ischemia. Cellular
and Molecular Biology 48: 671-679.
Santos RF, Galduró ZJC, Barbieri A, Castiglioni ML & Ytaya-Bueno OF (2003) Cognitive performance, SPECT, and bood viscosity in elderly non-demented people using Gingko biloba. Pharmacopsychiatry 36: 127-133.
Schenkel EP, Gosmann G & Petrovick PR (2003) Produtos de origem vegetal e o desenvolvimento de medicamentos. In: Simões CMO, Schenkel EP, Gosmann G, Mello JCP, Mentz LA & Petrovick PR org. Farmacognosia: da planta ao medicamento. 5 ed. Florianópolis: Porto Alegre, Editora da UFSC: Editora da UFRGS, p.371-400.
Smith JV & Luo Y (2004) Studies on molecular mechanisms of Gingko biloba extract. Applied Microbiological Biotechnology 64: 465-472.
Schulz V, Hänsel R & Tyler VE (2002). Ginkgo no tratamento de deficiência cognitiva. In: Fitoterapia racional. 4 ed. Barueri: Manole, p 42-56.
Wei T, Ni Y, Hou J, Chen C, Zaho B & Xin W (2000) Hydrogen peroxide-induced oxidative damage and apoptosis in
cerebellar granule cells: protection by Ginkgo biloba extract. Pharmacology Research 41: 427-433.
WHO (1999). Folium Ginkgo. In: WHO monographs on selected medicinal plants. Geneve: World Health Organization. 1: 154-163.
Yoshikawa T, Naito Y & Kondo M (1999) Ginkgo biloba leaf extract: review of biological actions and clinical applications. Antioxidants & Redox Signalling 1: 469-480.
Zhu W, Chen G, Hu L, Luo X, Gui C, Luo C, Puah CM, Chen K & Jiang H (2005) QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR. Bioorganic & Medicinal Chemistry 13: 313-322.
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