Plants and their extracts
administration and bioavailability of phytochemicals applied on the skin
Abstract
Several researches have been developed to evaluate the absorption of phytochemicals throughout the skin, considering the hard permeation of those phytopharmakons that frequently occur as â-glucosides that are easily soluble in water, and therefore, showing few expectations of skin absorption. The use of permeation enhancers has been proposed to intensify the bioavailability of those pharmakons applied on the skin. The percutaneous system of drug administration is useful to bypass the usual hepatic metabolism that happens after oral administration, what also contribute to enhancing the systemic bioavailability, and it is of easy application when compared to other conventional pharmaceuticals. We could observe in this research that there is a growing interest of Cosmetic Industry on applied properties of plant extracts, since it is an opened and valuable market.
Keywords:
Downloads
References
Amato M, Hueppi P, Isenschmid M & Schneider H (1992) Developmental aspects of percutaneous caffeine absorption in premature infants. American Journal of Perinatology 9: 592-594.
Ansel HC, Popovic NG & Allen Jr LV (2000) Farmacotécnica: formas farmacêuticas e sistemas de liberação de fármacos. 6 ed. São Paulo: Premier.
Bonina FP, Carelli V, Di-Colo G, Montenegro L & Nannipieri, E (1993) Vehicle effects on in vitro skin permeation of and stratum corneum affinity for model drugs caffeine and testosterone. International Journal of Pharmaceutics (Amsterdam) 100: 41-47.
Bonina FP, Bader S, Montenegro L, Scrofani C & Visca M (1992) Three phase emulsions for controlled delivery in the cosmetic field. International Journal of Cosmetic Science 14: 65-74.
Botsaris AS & Machado PV (1999) Flora Medicinal. 1ª edição. Volume I. Rio de Janeiro: Editora J Monteiro da Silva,.
Brounaugh RL & Franz TJ (1986) Vehicle effects on percutaneous absorption: In vivo and in vitro comparisons with human skin. British Journal of Dermatology 115: 1-12.
Brounaugh RL & Stewart RF (1986) Methods for in vitro percutaneous absorption studies: VI. preparation of the barrier layer. Journal of Pharmaceutical Sciences 75: 487-491.
Bucks DAW, Hostynek JJ, Hinz RS & Guy RH (1993) Uptake of two zwitterionic sufactants into human skin in vivo. Toxicology and applied Pharmacology 10: 224-227.
Calabrese V, Randazzo SD, Catalano C & Rizza V (1999) Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology. Drugs Experimetal and Clinical Research 5: 219-225.
Calabrese V, Scapagnini G, Catalano C, Bates TE, Dinotta F, Micali G & Giuffrida-Stella AM (2001) Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract. International Journal of Tissue Reactions 2: 51-58
Consoli A (2003) Chronic venous insufficiency: an open trial of
FLEBS Crema. Minerva Cardioangiologica 4: 411-416.
Ferreira AO (2002) Guia Prático da Farmácia Magistral. 2ª ed. Juiz de Fora: Editora Ferreira.
Gartner LP & Hiat JL (2002) Atlas colorido de histologia. Tra-dução de Leila Francisca de Souza, Maria das Graças Fernandes Sales. Rio de Janeiro: Guanabara Koogan.
Idson B (1985) Percutaneous absorption enhancers. Drugs Ex-perimental and Cosmetic Industry 137: 30.
Junqueira LC & Carneiro J (1999) Histologia básica. 9. ed. Rio de Janeiro: Guanabara Koogan.
Kim YH, Yang HE, Park BK, Heo MY & Kim HP (2002) The extract of the flowers of Prunus persica, a new cosmetic ingredient, protects against solar ultraviolet-induced skin damage in vivo. Journal of Cosmetic Science 1: 27-34.
Lachman L, Lieberman H & Kaning JL (2001) Teoria e prática na indústria farmacêutica. Tradução de João F. Pinto, Ana Isabel Fernandes. 2 v. Lisboa: Fundação Calouste Gulbenkian.
Lin SY & Chang HP (1997) Induction of superoxide dismutase and catalase activity in different rat tissues and protection from UVB irradiation after topical application of Ginkgo biloba extracts. Methods and Findings in Experimental and Clinical Pharmacology 6: 367-71.
Minghetti P, Casiraghi A, Cilurzo F & Montanari L (2000) Development of local patches containing melilot extract and ex vivo - in vivo evaluation of skin permeation. European Journal Pharmaceutical Science 2: 111-117.
Nerya O, Vaya J, Musa R, Israel S, Bem-Arie R & Tamir S (2003). Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. Journal of Agricultural and Food Chemistry 5: 1201-1207.
Oberthur C, Heinemann C, Elsner P, Benfeldt E & Hamburger M (2003) Comparative study on the skin penetration of pure tryptanthrin and in Isatis tinctoria extract by dermal microdialysis coupled with isotope dilution ESI-LC-MS. Planta Medica 69: 385-389.
Prista LN, Bahia MF & Vilar E (1995). Dermofarmácia e cosméti-ca. Lisboa: Editora ANF, 2 v.
Remington JP (1995) Remington: ciência y prática de la farmacia. Tradução de Octávio A . Giovanniello. et al. 19. ed. Pennsylvania: Mark Publishing Company.
Ressmann S, Biber A, Wonnemann M, Schug B, Blume HH & Müller WE (2002) Influence of pharmaceutical quality on the bioavailability of active components from Ginkgo biloba preparations. Journal of Pharmaceutical Pharmacology 5: 1507-1514.
Robbers JE, Speedie MK & Tyler VE (1997) Ginkgo. In: Farmacognosia e farmacobiotecnologia. São Paulo: Edito-rial Premier, pp. 100-101.
Röpkep CD, Kaneko TM, Rodrigues RM, Silva VV, Barros S, Sawada TCH; Kato MJ & Barros SBM (2002) Evaluation of percutaneous absorption of 4-nerolidycathecol from four topical formulations. Methods and Finds in Experimental and Clinical Pharmacology 1-2: 109-116.
Roskos KV, Maibach HI & Guy RH (1989) The effect of aging on percutaneous absorption in man. Journal of Pharmacokinetics and Biopharmaceutics 17: 617-630.
Rothman S (1954) Physiology and biochemistry of the skin, Chicago: Chicago University Press, 1954.
Schempp CM, Windeck T, Hezel S & Simon JC (2003) Topical treatment of atopic dermatitis with St. John’s Wort cream a randomized, placebo controlled, double blind half-side comparison. Phytomedicine 3: 31-37.
Sekiya K, Kadota S, Katayama K, Koizumi T & Namba T (1997) Study on baths with crude drug. III. The effect of ligustici chuanxiong rhizome extract on the percutaneous absorption of some natural compounds. Biological and Pharmaceutical Bulletin 9: 983-987.
Tregear RT (1996) Physical functions of the skin. New York: Academic Press.
How to Cite
License
Esta licença permite que outros distribuam, remixem, adaptem e criem a partir do seu trabalho, mesmo para fins comerciais, desde que lhe atribuam o devido crédito pela criação original.
