Evaluation of the toxic, cytotoxic and genotoxic effects of the crude extract from Solanum cordifolium Dunal and Solanum torvum Sw.
Abstract
This study evaluated the toxic, citotoxic and genotoxic effects of the hidroalcoholic crude extract from leaves of the species Solanum cordifolium and Solanum torvum, using the median lethal doses assay (ML50) in Swiss mice (Mus musculus), the Allium cepa test system (1, 2, and 3mg/mL) and the micronucleus assay on rat bone marrow cells. The results from the Allium cepa test showed that S. cordifolium do not present toxic, citotoxic or genotoxic effects in the tested concentration, but have high toxicity in the LD50 test (323mg/kg) and present citotoxic effect on rat bone marrow erythrocytes in the micronucleus assay. The extract from S. torvum presented less toxicity in the LD50 test in mice (11.733mg/kg), but presented clastogenic effect in the Allium cepa test and micronucleus assay.
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References
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