Substâncias bioativas de origem vegetal no tratamento da psoríase
Resumo
As doenças da pele afetam a conformação e a estrutura das células, regiões como epiderme e derme. A epiderme é a camada mais externa da pele, constituída de 95% de queratócitos e 5% melanócitos, células de Langherans e Merkel. A epiderme é dividida em quatro camadas principais, onde depende do estado de diferenciação de queratócitos. A camada basal é constituída por uma única camada de queratócitos, estas células proliferam, comprometendo células filhas, finalizando na formação do estrato córneo. A maioria das doenças da pele constitui distúrbios proliferativos, crônicos e inflamatórios, onde fatores genéticos e ambientais contribuem para o seu desenvolvimento. A psoríase é uma doença inflamatória crônica da pele e é provavelmente a doença de pele mais prevalente imunomediada em adultos, Para o tratamento da psoríase utiliza as plantas em vários países da qual se temos: Aloe vera L. (Liliaceae), Saccharum officinarum L. (Poaceae), Verbena officinalis L. (Verbenaceae), Acanthus mollis L. (Acanthaceae), Ecballium elaterium Rich. (Cucurbitaceae), Parietaria officinalis L. (Urticaceae), Verbascum sinuatum L. (Scrophulariaceae), Agave americana L. (Agavaceae), Inula viscosa Ait. (Asteraceae), Artemisia arborescens L.(Asteraceae), Rhagadiolus stellatus DC (Asteraceae), Curcuma longa L. (Zingiberaceae), Baphicacanthus cusia (Nees) Bremenk. (Acanthaceae), Polygonum tinctorium Aiton (Polygonaceae), Isatis indigotica Fortune (Brassicaceae), Indigofera tinctoria L. (Fabaceae), e Strobilanthes formosanus S.Moore (Acanthaceae).
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Referências
Aggarwal BB, Harikumar KB (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. The International Journal of Biochemistry & Cell Biolog y 41: 40–59.
Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F (2000). Traditional medicine as a source of new therapeutic agents against psoriasis. Fitoterapia 71:S13-S20.
Bergman R, Ramon M, Wildbaum G, Avitan-Hersh E, Mayer E, Shemer A, Karin N. (2009). Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor- and interferon-. J ournal of Dermatological Science 56:163-167.
Casanova JM, Sanmartín V, Soria X, Ferran M, Pujol RM, Ribera M. (2009). Tratamiento tópico de la psoriasis. Piel 24: 52-7.
Carrascosa JM, López-Estebaranz JL, Carretero G, Daudén E, Ferrándiz C, Vidal D, Belinchón I, Sánchez-Regaña M, Puig L (2011). Narrowband UV-B, monochromatic excimer laser, and photodynamic therapy in psoriasis: a consensus statement of the Spanish Psoriasis Group. Academy of Dermatolog y and Venereolog y 102: 175-186.
Carvalho MCG, Pires RL, Florindo WS, Cavalcanti ASS (2010). Evidências para o uso de Indigo naturalis no tratamento da psoríase tipo placa: uma revisão sistemática. Natureza on line 8: 127-131.
Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD, Jones PH (2007). A single type of progenitor cell maintains normal epidermis. Nature. 446: 185-189.
Conforti F, Marrelli M, Menichini F, Bonesi M, Statti G, Provenzano E, Menichini F (2009). Natural and Synthetic Furanocoumarins as treatment for Vitiligo and Psoriasis. Current Drug Therapy 4: 38-58.
Fonacier LS, Dreskin SC, Leung DYM (2010). Allergic skin diseases. Journal Allerg y Clinical Immunolog y 125:138-149.
Guttman-Yassky E, Nograles KE, Krueger JG (2011). Contrasting pathogenesis of atopic dermatitis and psoriasis. Journal Allerg y Clinical Immunolog y 127: 1010-1018.
Kalb RE, Bagel J, Korman NJ, Lebwohl MG, Young M, Horn EJ, VanVoorhees AS (2009). Treatment of intertriginous psoriasis: From the Medical Board of the National Psoriasis Foundation. Journal of the American Academy of Dermatolog y 60: 120-124.
Kharaeva Z, Gostova E, De Luca C, Raskovic D, Korkina L (2009). Clinical and biochemical effects of coenzyme Q10, vitamin E and selenium supplementation to psoriasis patients. Nutrition 25: 295-302.
Kurd SK, Smith N, VanVoorhees AS, Troxel AB, Badmaev V, Seykora JT, Gelfand JM (2008). Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial. Journal of the American Academy of Dermatolog y 58: 625-631.
Lai-Cheong JE, McGrath JA (2009). Structure and function of skin, hair and nails. Basic Science 37: 223-226.
Lapolla W, Yentzer BA, Bagel J, Halvorson CR, Feldman SR (2011). A review of phototherapy protocols for psoriasis treatment. Journal of the American Academy of Dermatolog y 64:936-949.
Ledon N, Casaco A, Remirez D, Gonzalez A, Cruz J, Gonzalez R, Capote A, Tolón Z, Rojas E, Rodriguez VJ, Merino N, Rodriguez S, Ancheta O, Cano MC (2007). Effects of a mixture of fatty acids from sugar cane (Saccharum officinarum L.) wax oil in two models of inflammation: Zymosan-induced arthritis and mice tail test of psoriasis. Phytomedicine 14: 690-695.
Lin YK, Leu YL, Yang SH, Chen HW, Wang CT, Pang JHS (2009). Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component. Journal of Dermatological Science 54: 168-174.
Murugananthama N, Basavaraj KH, Dhanabal SP, Praveen TK, Shamasundar NM, Rao KS (2011). Screening of Caesalpinia bonduc leaves for antipsoriatic activity. Journal of Ethnopharmacolog y 133: 897–901.
Nograles KE, Krueger JG (2011). Anti-cytokine therapies for psoriasis. Experimental Cell Research 317: 1293-1300.
Ortega C, Fernández AS, Carrillo JM, Romero P, Molina IJ, Moreno JC, Santamaría M (2009). IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. Journal of Leukocyte Biolog y 86: 435-443.
Patel RV, Clark LN, Lebwoh Ml, Weinberg JM (2009). Treatments for psoriasis and the risk of malignancy. Journal of the American Academy of Dermatolog y 60: 1001-1017.
Pietrovski EF, Paludo KS, Mendes DAGB, Guimarães FSF, Veiga SS, Buchi DF, Fonseca RG, Zampronio AR, Bader M, Pesquero JB, Ferreira J, Otuki MF, Cabrini DA (2011). B1 and B2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice. Journal of Dermatological Science 64: 23-30.
Rodriguez ID, Gutierrez OS, López OR, Naranjo MF (2006). Benefícios del Aloe vera l. (sábila) en las afecciones de la piel. Revista Cubana de Enfermería 22: 1-5.
Shelling ML, Federman DG, Prodanovich S, Kirsner RS (2008). Psoriasis and Vascular Disease: An Unsolved Mystery. The American Journal of Medicine 21: 360-365.
Smith N, Weymann A, Tausk FA, Gelfand JM (2009). Complementary and alternative medicine for psoriasis: A qualitative review of the clinical trial literature. Journal of the American Academy of Dermatolog y 61: 841-856.
Soto-Sánchez J, Santos-Juanes J, Coto-Segura P, Coto E, Díaz M, Rodríguez I, Alvarez V (2010). Genetic variation at the CCR5/ CCR2 gene cluster and risk of psoriasis and psoriatic arthritis. Cytokine 50: 114–116.
Traub M, Marshall K (2007). Psoriasis pathophysiology, conventional, and alternative approaches to treatment. Journal of Clinical Therapeutic 12: 319-330.
Wilkinson JD, Williamson EM (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. Journal of Dermatological Science 45:87-92.
Wozel G (2008). Psoriasis treatment in difficult locations: Scalp, nails, and intertrignous areas. Clinical Dermatolog y 26: 448-459.
Wu Y, Lu Z, Chen Y, Xue F, Chen X, Zheng J (2010). Replication of association between interleukin-23 receptor (IL-23R) and its ligand (IL-12B) polymorphisms and psoriasis in the Chinese Han population. Human Immunolog y 71:1255-1258.
Yogeeta A, Petkar KC, Sawant KK (2010). Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. International Journal of Pharmaceutics 401: 93-102.
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